Single doublecortin gene therapy significantly reduces glioma tumor volume

Mutation of NRAS but not KRAS significantly reduces myeloma sensitivity to single-agent bortezomib therapy.

Various translocations and mutations have been identified in myeloma, and certain aberrations, such as t(4;14) and del17, are linked with disease prognosis. To investigate mutational prevalence in myeloma and associations between mutations and patient outcomes, we tested a panel of 41 known oncogenes and tumor suppressor genes in tumor samples from 133 relapsed myeloma patients participating in...

Adjuvant therapy versus surgery in controlling seizure in patients with low-grade glioma tumor

Introduction: Since surgical treatment for tumorous lesions does not always lead to complete patient recovery, it is possible for the attacks to continue. To help plan for the patients' health, this study aimed to compare the therapeutic effects of adjuvant therapy and surgery in controlling seizure of low-grade glioma (LGG) patients in Firoozgar Hospital in 2013-2014. Methods: In this analyti...

The role of relative cerebral blood volume obtained from Perfusion Weighted Imaging-MRI in glioma tumor grading before surgery

Introduction: Glioma is the most common type of brain malignancy among adults. Treatment for this type of tumor involves surgery, radiotherapy, and in higher grades, including chemotherapy. The precise grading of the tumor is critical for treatment planning and prognosis determining. Considering the possibility of problems such as errors in tissue sampling during surgery, as we...

Response assessment in high-grade glioma: tumor volume as endpoint.

Gene therapy for high-grade glioma.

High-grade glioma is the most frequently occurring primary brain tumor and is associated with a poor prognosis. Current treatment regimens have had only a modest effect on the progressive course despite recent advances in surgery, radiotherapy, and chemotherapy. Gene therapy for brain tumors represents a novel and promising therapeutic approach and has been investigated clinically for the last ...